Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex
نویسندگان
چکیده
منابع مشابه
Targeting folate receptor alpha for cancer treatment
Promising targeted treatments and immunotherapy strategies in oncology and advancements in our understanding of molecular pathways that underpin cancer development have reignited interest in the tumor-associated antigen Folate Receptor alpha (FRα). FRα is a glycosylphosphatidylinositol (GPI)-anchored membrane protein. Its overexpression in tumors such as ovarian, breast and lung cancers, low an...
متن کاملSynthesis of folate-chitosan nanoparticles loaded with ligustrazine to target folate receptor positive cancer cells
In addition to its vasodilatory effect, ligustrazine (LZ) improves the sensitivity of multidrug resistant cancer cells to chemotherapeutic agents. To enhance the specificity of LZ delivery to tumor cells/tissues, folate‑chitosan nanoparticles (FA‑CS‑NPs) were synthesized by combination of folate ester with the amine group on chitosan to serve as a delivery vehicle for LZ (FA‑CS‑LZ‑NPs). The str...
متن کاملImmunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer.
PURPOSE Cancer cells are highly dependent on folate metabolism, making them susceptible to drugs that inhibit folate receptor activities. Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. We investigated the functional mechanisms of MORAB-003 (farletuzumab), a humanized mAb against FRα, in ovarian cancer models. EXPERIMENTAL DESIGN We first ...
متن کاملUtilizing the folate receptor for active targeting of cancer nanotherapeutics
The development of specialized nanoparticles for use in the detection and treatment of cancer is increasing. Methods are being proposed and tested that could target treatments more directly to cancer cells, which could lead to higher efficacy and reduced toxicity, possibly even eliminating the adverse effects of damage to the immune system and the loss of quick replicating cells. In this mini-r...
متن کاملRecruiting cytotoxic T cells to folate-receptor-positive cancer cells.
One new class of biologics that is generating a great deal of interest as next-generation cancer therapeutics are bispecific antibodies that simultaneously target the cluster of differentiation 3 (CD3) protein and tumor-associated antigens to recruit cytotoxic T cells from the patient s own immune system to eliminate cancer cells. Examples include the first approved bispecific antibody in Europ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Signal Transduction and Targeted Therapy
سال: 2020
ISSN: 2059-3635
DOI: 10.1038/s41392-020-0115-0